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E., Hirst, W

Differentially expressed proteins with p values 0.05 and fold changes 1 were selected

While the findings underscore spermidines potential as an agent for healthy aging, the underlying mechanisms and its effects on telomeres and longevity require further elucidation in human studies

Neuroprotection Emerging Evidence Evidence Rating: Emerging (Interesting animal data, limited scope) Neurological applications show promise but require more research: Dopaminergic system protection Peripheral nerve regeneration Traumatic brain injury Alcohol-related neurological damage The GABAergic system interactions and NO modulation provide mechanistic support, but this area needs more study