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1 It promotes glucose-dependent insulin secretion, suppresses glucagon release, slows gastric emptying, and contributes to appetite regulation through central nervous system pathways

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However, the medications, which are administered by injection, are controversial because they can cause side-effects such as nausea and fatigue, and it is thought weight loss will reverse when the drugs are stopped

We show that senescent cells are primed for ferroptosis, displaying high levels of oxidative stress and intracellular Fe 2+ , but also upregulate GPX4, which prevents the accumulation of oxidized lipids