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A comprehensive review in Nature Reviews Disease Primers described B12 deficiency as a significant and underrecognized public health concern, particularly among older adults, individuals with gastrointestinal conditions, and those following plant-based diets (Green et al., Nat Rev Dis Primers , 2017)

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Circadian Rhythm Synchronization: IF may help synchronize circadian rhythms, which are often disrupted in RA and obesity, leading to improved metabolic function and reduced inflammation 44

52 In the liver, SIRT1 plays a central role at the intersection of lipid metabolism, insulin sensitivity, and inflammatory signaling, coordinating metabolic adaptation through a network of regulatory pathways