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Unmatched Weight Loss Magnitude Retatrutide produced up to 24% total body weight reduction in Phase 2 clinical trials a figure that exceeds every approved GLP-1 agent currently on the market, including tirzepatide (~21%) and semaglutide (~15%)

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However, the cognitive enhancing effects of PregS in healthy subjects are unlikely to be due to the PREG metabolite ALLO since acute administration of this and other GABAergic modulating neurosteroids to healthy subjects inhibits learning and memory function in a manner similar to benzodiazepines (187191)