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Data collection and quality assessment In accordance with the established inclusion criteria, two reviewers meticulously extracted the following data from the selected studies: the name of the first author, year of publication, participants race and ethnicity, study design, number of cases and controls, family history of cancer, body mass index, age, clinical outcomes, type of drug administered, and stages of CRC
Successful therapeutic strategies for the treatment of bone metastases include radium 223, bisphosphonates, and receptor activator of nuclear factor kappa-B ligand (RANKL) inhibitor denosumab