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In patients with chronic inflammation, the immune system remains continuously activated, primarily due to a deficiency in the number and function of Breg cells in both the circulatory system and the sites of inflammation [72]

Although acetoacetate (ACA), -hydroxybutyrate (-HB), and acetone are all KBs that provide alternative energy substrates for the brain, research investigating the impact of KD on neurodegenerative disorders predominantly emphasizes -HB