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As a review in The Journal of Clinical Endocrinology & Metabolism describes, the warning specifically advises against these drugs for people with a personal or family history of medullary thyroid carcinoma or MEN2, a guidance rooted in rodent studies rather than common thyroid conditions

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During a mean follow-up of 10.6 months, adults receiving an SGLT2 inhibitor had a lower risk for a CV event than those receiving a DPP-IV inhibitor (HR = 0.72

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If untreated, people deficient in carnitine are at risk for cardiomyopathy (heart muscle damage) and even sudden cardiac death

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