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The oral intake of glutathione has always been the limiting factor** for its use in food supplements: the human intestine contains significant quantities of the enzyme gamma-glutamyltranspeptidase, responsible for the degradation of glutathione after oral ingestion

However, maturation of erythrocytes and conversion of erythroblasts to mature erythrocytes during erythropoiesis is accompanied by enucleation and organelle clearance [32]

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Ferrous iron can catalyze the formation of hydroxyl radicals through the Fenton reaction, which initiates LPO [78]