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Research suggests it may influence the transition into deeper rest stages by interacting with pathways that govern sleep architecture, while separate findings explore its role in modulating corticotropin-releasing factor activity, a key driver of the bodys stress hormone response, to encourage a calmer and more balanced internal environment conducive to overnight restoration

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Nuttall et al.[37] studied the effect of chronic ingestion of therapeutic doses of APAP (1 gram, 4 times per day, for 2 weeks) on serum antioxidant capacity, and found a gradual and progressive decline to a level about 85% of control value