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Notably, C 10 is the PE in a (non-enteric) oral tablet of MK-0616, a macrocyclic PCSK9 inhibitor, which recently entered Phase III trials in 2024 for LDL cholesterol reduction ( 6 Chitosan and TJs Chitosan is a linear, semi-crystalline polysaccharide derived from the deacetylation of chitin and consists of N-acetyl-D-glucosamine and D-glucosamine units (Quinn et al., 2022)