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recently discovered that high sodium lactate concentrations boosted histone H3 lysine 27 acetylation (H3K27ac) levels at the T cell factor 7 (TCF7) super-enhancer locus by inhibiting histone deacetylase activity

Primarily, it stimulates insulin secretion from the pancreas when blood glucose levels are elevated, whilst simultaneously suppressing the release of glucagon, a hormone that raises blood sugar

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Immunophenotyping showed that aCD3 therapy, alone or combined with GLP1-E2, significantly reduced circulating CD3 T cells, an effect not observed in the other groups (Fig