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FIGURE 1 In vitiligo patients, high IFN- expression has been implicated in an aggressive and permanent IS response (IFN- CXCL10 (C-X-C Motif Chemokine Ligand 10) CD8 + T cells) (Xie et al., 2016) targeting the population of epithelial cells throughout the body causing visual (Ma et al., 2021) and vascular dysfunction (Dwivedi et al., 2013), leading them to apoptosis without replacement, a phenotypic trait of vitiligo, identified by white spots in the skin, which signalize the absence of melanocytes at the site (Rashighi et al., 2014)

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doi: 10.14309/ctg.0000000000000120