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found that circ_0001273, as a cancer-promoting factor that upregulates SLC1A5 expression by binding to miR-622, which increases Gln uptake by tumor cells, consequently enhancing tumor growth and inhibiting cell apoptosis (57)

One of the main criteria for classifying variants is to categorize them into null variants, which result in a non-functional protein or no protein at all, and missense variants, which produce a protein with an altered amino acid sequence that may retain residual function, have reduced function, or even acquire a different function from the original protein

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