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Future studies should also consider the impact of extra-neurological injury such as renal or hepatic impairment on the PK of 7,8-DHF

A set of no-cell control group containing only the culture medium without cells were prepared to serve as negative control to determine background fluorescence that might be present

Collectively, these findings indicate that disruption of the glucagon receptor not only modifies the gene expression profile of cells but also alters the pancreatic islet microenvironment

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