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Approved by the FDA in 2010 under the brand name Egrifta, tesamorelin was initially indicated for HIV-associated lipodystrophy a condition characterized by severe visceral fat accumulation driven by both the virus and antiretroviral medications

The 10-year cumulative incidence of MACE was 23.7% (95% CI 20.027.6%) in the metabolic surgery group and 34.0% (95% CI 28.144.2%) in the GLP-1 RA group (adjusted HR 0.65 (95% CI 0.510.82)

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If successful, CAQK could serve as a delivery vehicle for other therapeutic peptides, concentrating their effects exactly where damage has occurred