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It suppresses ECM degradation, counteracts RSL3 mediated inhibition of GPX4, increases intracellular GSH levels and the GSH/GSSG ratio, reduces MDA content, and inhibits activation of the MAPK/NF-KB pathways, thereby protecting chondrocytes from ferroptosis (156)

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Intervention trials indicate that combined probiotic and prebiotic supplementation can significantly decrease TPOAb and TgAb concentrations, improve gut barrier integrity, and restore microbial diversity in HT patients (Liu et al