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Patients who prefer a well-studied option or are concerned about long-term safety data

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GH-Axis Side Effects Are Biologically Plausible Because CJC-1295 is designed to increase GH-axis signaling, GH-related effects such as fluid retention, edema, joint discomfort, paresthesias, and carpal-tunnel-like symptoms are relevant safety endpoints, even when not proven specifically for every form of CJC-1295

A key finding was its ability to reduce phosphorylation of myosin light chain-2 through inhibition of the ROCK pathway, a central regulator of perijunctional actomyosin contraction and barrier leakiness