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gonorrhoeae , and that in several meningococcal lineages the island contains an additional gene, kbuT encoding a transporter from the 4-Toluene Sulfonate Uptake Permease (TSUP) family involved in transport of -ketobutyrate, an -keto acid particularly abundant in polymorphonuclear neutrophils (PMNs) (Mhling et al., 2003), which can be metabolized through the MCC, raising the hypothesis of a role of MCC during meningococcal host cell infection (Tal et al., 2025)

In certain instances, a reduced frequency of administration of intratympanic injections reduces the risk of permanent damage (e.g., perforation) to the ear drum

Merck Life Science N.V, Sigma, Netherlands, #NS02L-1ML) in PBS for 30 min