Transcriptomic analysis of iSPNs at the pre-symptomatic stage showed de-regulation of metabolic pathways, including upregulation of Gsto2 , encoding glutathione S-transferase omega-2 (GSTO2)
In microglia, persistent ISR activation disrupts lipid homeostasis by inducing lipogenic enzymes, including FASN, DGAT, and ACSL family members, thereby promoting LDs accumulation and ceramide-driven neurotoxicity [20, 21]
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Therefore, you can boost glutathione production in your body by consuming foods like avocados, citrus fruits, garlic and onions, bell peppers, etc