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Patients should seek urgent medical attention by contacting their GP, calling NHS 111, or attending an emergency department if they experience severe or persistent abdominal pain, particularly if it radiates to the back, or other symptoms that may suggest pancreatitis or gallbladder problems

reported that DHODH (Dihydroorotate dehydrogenase) coordinates with GPX4 by reducing ubiquitin formation in cancer cells, blocking the action of ferroptosis in mitochondrial intima [52], DHODH inhibitors induce ferroptosis and significantly inhibit tumor growth in solid tumors with low GPX4 expression, and the combination of ferroptosis inducer sulfasalazine and DHODH inhibitors has a good therapeutic effect in solid tumors with high GPX4 expression

Recurrent hypoglycaemic episodes necessitate urgent medication reviewdose reduction of insulin or sulfonylureas is typically required rather than discontinuation of Ozempic