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Using similar strategies for upstream positive regulators of GPX4, for example, upregulating SLC7A11 expression via gene therapy, can multi-targetedly enhance the cells overall antioxidant capacity and GSH supply, thereby indirectly supporting and enhancing GPX4 activity (Liao et al., 2024)

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Managing Multiple Missed Doses A more complex situation arises when an individual misses two or more weeks of their medication

The second is extending the interval between dose escalations beyond the recommended schedule, such as staying at 0.25 mg for eight weeks instead of four before increasing the dose