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So, while the debate between localized and systemic application will likely continue, the most consistent and logically sound approach for targeted ankle research points toward a localized, subcutaneous injection near the site of injury

A categorical shift from near-zero to clinically meaningful

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J Orthop Res 24:982989 Liu C, Aschbacher-Smith L, Barthelery N, Dyment N, Butler D, Wylie C (2011) What we should know before using tissue engineering techniques to repair injured tendons: a developmental biology perspective