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Alternatives There are some natural alternatives to laxatives and lifestyle changes that can help alleviate constipation: regular activity increasing daily intake of fiber drinking more water adding bulking agents, such as bran, to the diet There are four main types of laxatives

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no hepatic safety signal has been observed across the orforglipron clinical program, distinguishing it from the discontinued Pfizer oral GLP-1 candidates lotiglipron and danuglipron, both of which were terminated due to liver toxicity concerns

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