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When it is off, you are storing fat and feeling like a wet noodle

doi: 10.1530/EJE-11-0779 11 SistiECocoBMenconiFLeoMRocchiRLatrofaFet al

Perhaps most relevant to the GLP-1 conversation, a 2021 study published in Nature Microbiology identified a specific protein secreted by Akkermansia muciniphila, called P9, that directly stimulates GLP-1 secretion from intestinal L-cells