B activation and suppresses the release of TNF-?, IL-1?, and IL-6, decreasing chronic low-grade inflammation linked to aging and tissue degeneration 4
157 In a crossover trial performed by a different research group, scores on tests of psychological and mood symptoms, as well as sexual function, improved after six weeks of treatment with 3.5 grams of powdered maca per day relative to placebo in 14 postmenopausal women
Chang W, Zhang M, Li J, Meng Z, Wei S, Du H, Chen L, Hatch GM (2013) Berberine improves insulin resistance in cardiomyocytes via activation of 5-adenosine monophosphate-activated protein kinase
Preparing PT-141 nasal spray Why nasal spray: Avoids injections (needle-phobic) More convenient Slightly faster onset (30-60 min quicker) Lower bioavailability (~30% vs ~100% injection) Need higher dose to compensate Nasal spray supplies needed: Empty nasal spray bottle (10-15ml) Reconstituted PT-141 (higher concentration recommended) Syringe for transferring Small funnel (optional) Concentration for nasal spray: Higher concentration better (less volume per dose) Reconstitute 10mg PT-141 in 1ml water = 10mg/ml Or even 10mg in 0.5ml = 20mg/ml (very concentrated) Allows smaller spray volume Fewer sprays needed per dose Nasal spray dosing: Inject: 1.5mg dose Nasal equivalent: 3-5mg (lower absorption) 0.3ml of 10mg/ml concentration = 3mg nasal 0.5ml of 10mg/ml = 5mg nasal Typical: 2-3 sprays per nostril (0.1ml per spray) See complete PT-141 nasal spray guide for men for detailed protocols
