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Useful oxidative-damage markers may include urinary 8-OHdG , which reflects oxidative DNA damage, and lipid peroxides , which reflect oxidative damage to fats and cell membranes

Its actions, however, are highly context-dependent, and under conditions of NAD + depletion, specific cell types, dosing imbalances, or advanced disease, SIRT1 may exacerbate oxidative damage by impairing repair enzyme activity, exacerbating mitochondrial dysfunction, and weakening antioxidant responses

Supplements promising to give you the same results as prescription medications are overhyped

Disclaimer: For optimal results, perform a patch test before first use