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Defrere S, Van Langendonckt A, Vaesen S, Jouret M, Gonzalez Ramos R, Gonzalez D, et al

parkeri peptidoglycan remodeling via a cysteine requirement of periplasmic proteins such as autolysins, or via a specific role for cysteine in regulating autolysin gene expression, which will require further investigation

Although the detailed consequences of the overexpression of all these individual genes is difficult to assess, a few of them have been suggested to be of crucial importance in the development of certain phenotypic aspects ( APP ) (Salehi et al., 2007), the Glutamate Receptor, Ionotropic, Kainate 1 ( GRIK1 ) (Valbuena et al., 2019), the Regulator of CAlciNeurin 1 ( RCAN1 ) ( Dual-specificity tyrosine phosphorylation-Regulated Kinase 1A ( DYRK1A ) (Kim H

Rather than testing a handful of well-known genes, the platform uncovers much deeper mechanism-level drivers of response and non-response, including multiple novel pathways beyond classical GLP-1 biology