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Initial preclinical and clinical studies have suggested that semaglutide may reduce fat accumulation in the liver, attenuate inflammation and improve liver fibrosis associated with NAFLD

Gastrointestinal adverse events, meanwhile, were seen in similar amounts in the two groups

An in vitro study from isolating adult human testis suggests that 10 4 10 5 mol/L APAP exposure for 2448 h may alter testosterone and insulin-like factor 3 in Leydig cells ( ex vivo study from isolating human ovarian fragments displays that 10 3 10 8 mol/L APAP exposure for 7 days may decrease the total cell number ovaries and the KI67-positive cell density, induce cell death

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