Cigarette smoke exposure activates the molecular cascade that results in the production and release of NF-B ( in vitro , in cell culture, and in vivo , in animal models of cigarette smoke exposure (Zhong et al., 2006)
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Diabetes Insipidus While much rarer, and not specifically related to diabetes mellitus, diabetes insipidus (DI), which is characterized by extreme thirst (polydipsia) and frequent urination (polyuria) due to an inability of the kidneys to properly concentrate urine, has also been shown to involve dysregulation of the NRF2 pathway