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Quite a large majority of the people that go on GLP-1s do have some side effects

An early trial in 160 men and women diagnosed with a recent MI showed that oral L-carnitine (4 g/day) in addition to standard pharmacological treatment for one year significantly reduced mortality and the occurrence of angina attacks compared to the control (47)

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For example, combining Semax (peptide) with racetams (small molecule nootropics) can enhance neuroplasticity through both BDNF upregulation and AMPA receptor modulation