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The plausible main reason for -cell protective effects of GSH differing from other antioxidant effects is that GSH has multiple functions, such as maintaining levels of reduced glutaredoxin and glutathione peroxidase 35 and maintaining exogenous antioxidants such as vitamins C and E in their reduced (active) forms 36,37,38

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This pharmacokinetic profile distinguishes Dihexa from the parent angiotensin IV peptide, which does not cross the blood-brain barrier well and is rapidly degraded in circulation

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