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Reduced expression of PGC-1 partly underlies mitochondrial changes and correlates with neuronal loss in multiple sclerosis cortex

It also acts on the enzyme tyrosinase, which plays a role in melanin production, reducing the formation of dark pigments in the skin

Given that mitochondrial dysfunction is an important factor for ferroptosis (146), Parkins role in mitophagy suggests a potential link

demonstrated that administration of Fucoidan along with cerebrolysin in adult male SpragueDawley rats in cerebral ischemia model results in substantial decrease in neurological impairments and cerebral infarct volume (148)