Some observational studies have reported no increase in IBD exacerbations after GLP-1 RA initiation [6] and others have found treatment with GLP-1 RAs to be associated with reduced IBD-related hospitalisation and surgery [7]
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Moreover, our study revealed that GLP-1 analogs, including GLP-1, liraglutide, and exendin-4, along with the GLP-1 antagonist exendin 939, derived from exendin-4, which shares 53% sequence homology with native GLP-1 39 , effectively inhibited CAP-induced TRPV1 activation in mouse DRG neurons
Inositol at standard doses is well tolerated but can occasionally cause mild digestive effects