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We recommend drinking plenty of water

Common causes include liver disease (which releases stored B12), kidney disease (reducing B12 clearance), haematological malignancies, solid tumours, and excessive supplementation

Thus, going forward, it will be important to focus on dynamic changes observed in those proteins associated with mucosal barrier properties, rather than simply documenting terminal modifications as they are expressed in chronically inflamed mucosa

Also, IGF-I is secreted by the liver, which attracts circulating cancer cells drain and promotes colonization, proliferation, and the establishment of metastasis (185)