In a study involving 30 patients living with obesity and PCOS, those treated with liraglutide, either alone or in combination with metformin, for 12 weeks demonstrated significant improvements in glycemic control and fasting insulin levels [43]
Eur J Endocrinol 181(6):R211R234 Newsome PN, Buchholtz K, Cusi K, Linder M, Okanoue T, Ratziu V et al (2021) A placebo-controlled trial of subcutaneous semaglutide in nonalcoholic steatohepatitis
Cardiometabolic endpoint outcomes included the event rates of MACE, which were assessed during baseline, and 1st- and 2nd-year follow-up
Most gastrointestinal side effects of tirzepatide, including nausea and diarrhea, are most severe during the first few weeks of treatment or after dose increases and typically diminish within several days to weeks as the body adapts to the medication