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It enhances GABA-A receptor sensitivity, modulates serotonin and norepinephrine reuptake, and reduces pro-inflammatory cytokines, particularly IL-6, in animal models

However, spider veins also can be caused by such factors as aging, pregnancy, estrogen replacement therapy, sun damage and rosacea

Avoid freezing the reconstituted solution, since freezethaw can denature the peptides

It has been suggested that keratinocytes, through the release of biological mediators, proopiomelanocortin (POMC)-derived peptides, basic fibroblast growth factor, and endothelins, regulate proliferation and differentiation of melanocytes and stimulate melanogenesis through receptor-mediated signalling pathways [20]