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Specific gene variants, such as GLP1R rs6923761 and GIPR rs1800437, affect receptor sensitivity and downstream signaling efficiency
Instead, it supports insulin sensitivity, blood sugar control, muscle function, and sleep all of which make it easier to maintain a calorie deficit, avoid rebound cravings, and keep your metabolism healthy during weight loss
Over the long term, these metabolic changes make it hard to maintain weight loss, particularly when coupled with other forces such as hormonal changes
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