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Menasche, G

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The coexistence of mental health disorders and chronic physical conditions presents significant clinical and economic challenges, including reduced treatment adherence, greater complexity in disease management, and poorer health outcomes (Zeleke et al., 2025)

Some studies indicate that the risk is also due to higher homocysteine levels[ref], while other studies show that it may be due to the methylation of certain genes.[ref] Meta-analyses showed that the MTHFR C677T variant increased the risk of migraines with aura for all population ancestry groups