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One feature that has complicated the identification of the mechanisms by which the changing melatonin signal regulates annual reproductive changes in seasonally breeding mammals is the fact that in the Syrian hamster (a long day breeder) the reproductive organs are atrophic in the winter which prevents mating, pregnancy and delivery of the young (30)

New England Journal of Medicine , 375(19), 18341844

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[1] Dehydration from gastrointestinal side effects can increase the risk of acute kidney injury