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Additional observed toxic mechanisms included loss of MMP, upregulation of the proapoptotic protein Bcl-2-associated X protein (BAX), and downregulation of antiapoptotic markers such as B-cell lymphoma 2 (Bcl-2), poly ADP ribose polymerase (PARP), and caspase-3 [134]

J Clin Nurs 21(2122):31983204 AlAjmi M, Al-Ghamdi S (2021) Translation and validation of the Arabic version of the osteoarthritis quality of life questionnaire (OAQoL) in Saudi patients with osteoarthritis