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S-mediated standard reaction conditions N -phenoxyacetamides ( 1 ) (0.20 mmol), N -substituted thiophthalimides ( 4 ) (0.24 mmol) and 2,6-lutidine (1.0 eq.) were weighed into a 10 mL tube, to which was added TFE (2.0 mL)

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2) and we ensured that the distribution of treatment years was similar between training and testing data sets (Fig