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If a drug selected for IRA negotiation has its Medicare net price reduced by 30% to 50% before patent expiry, a biosimilar or generic entering at 20% below that negotiated price is in a smaller total market than historical analogues would suggest

American Journal of Physiology Renal Physiology 317(6):F1450F1461 Pereira ADS, Miron VV, Castro MFV, Bottari NB, Assmann CE, Nauderer JN, Bissacotti BF, Mostardeiro VB, Stefanello N, Baldissarelli J, Palma TV, Morsch VMM, Schetinger MRC (2023) Neuromodulatory effect of the combination of metformin and vitamin D3 triggered by purinergic signaling in type 1 diabetes induced-rats

Reductions in cigarettes per day were also seen

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