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The drug prescribed for weight loss purposes for adults who have a high body mass index (BMI) and may benefit from losing weight, regardless of whether they have diabetes or not

Once the adipose tissue expandability exceeded limit under overnutrition, excess lipids and toxic lipid metabolites (FFA, diacylglycerol, ceramide) accumulated in non-adipose tissues, thus leading to lipid-induced toxicity (lipotoxicity) and developed IR in liver and muscle

This protective effect is attributed to the ability of Lactobacillus casei Shirota (LcS) to stimulate the secretion of TNF- and interleukin-12 (IL-12), cytokines that are well-established drivers of enhanced NK cell cytotoxic activity (194)

Nitric oxide donors and cardiovascular agents modulating the bioactivity of nitric oxide