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However, in the process of clinical translation, PDEVs still face many challenges, including the standardization of their extraction and characterization methods, the optimization of efficient drug loading strategies, and the study of the mechanism of action in improving the bioavailability of orally insoluble drugs, macromolecules and nucleic acid drugs (Nemati et al., 2022), The in-depth exploration of these problems will provide new research ideas and theoretical basis for the development of efficient and safe reproductive medicine drug delivery system

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Individuals with bone marrow disorders 10 , 11