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Stage 4: Advanced gout (chronic tophaceous gout) This is a stage of chronic gouty arthritis, in which there are lumps of uric acid, or tophi (see Figure 2: Illustration of Toe Joint With Gouty Tophus ), frequent attacks of acute gout, and often a degree of pain even between attacks (see Figure 3: Progression of Gout )

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However, in atropine-rats, unlike the mutually counteracting effect on miosis, they could not antagonize each others effect [12]