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In Drosophila , inactivation of positive regulators of insulin signaling (e.g., IR, IRS-1-4) decreases cell size, whereas overexpression of these components has the opposite effect

There are multiple potential predisposing/etiologic factors, including cancer itself, treatment-related adverse effects, physiologic complications, impaired performance status, and psychological comorbidities, such as depression [65, 67]

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