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These studies have identified TAMs with immunosuppressive phenotypes, such as those marked by high expression of CD206 (a hallmark of M2-like macrophages), which co-exist with populations producing key pro-inflammatory cytokines like TNF-

NAC elevates intracellular GSH, suppresses H 2 O 2 accumulation, and blocks the NLRP3-CASP1-GSDMD pathway in vitro and in vivo 59-61

IGF-1 LR3 may offer potential advantages for in vitro research by better-supporting cell viability and protein production compared to other common cell stimulants often exposed to research models in in laboratory settings

doi:10.1016/j.csm.2019.08.007 Nin DZ, Chen YW, Mandalia K, et al