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Truncated glucagon-like peptide 1, an insulin-releasing hormone from the distal gut

Because hyperuricemia is a risk factor for gout, which usually manifests itself as an intense episode of pain in the metatarsophalangeal joint of the big toe, caused by the deposition of uric acid crystals and accompanied by swelling, possible redness, and inflammation

10.1210/en.2003-2350 Endocrinology 71 GuertinD

When intra-portal insulin levels are increased (e.g., obesity, Cushings syndrome, or due to treatment with glucocorticoids and glucagon-like peptide 1 receptor agonists) or decreased (e.g., malnutrition, anorexia nervosa and type 1 diabetes mellitus), these changes secondarily alter hepatic GH sensitivity resulting in a secondary association with discordant GH and IGF-I levels (e.g., high GH/low IGF-I levels or low GH/high IGF-I levels, respectively)