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For more on what GLP-1 is and an overview of other GLP-1 agonists, please see the following article on this website: A simple primer on what GLP-1 agonists are Relatively common side effects In clinical trials, side effects that occurred on semaglutide injection (Wegovy ) with at least a 2% drug-placebo difference were: 1

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Eli Lillys December 2025 press release reported average weight loss of up to 71.2 lbs at the highest dose, alongside substantial relief from osteoarthritis pain