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According to the Ro blog, because Ozempic is a type 2 diabetes drug, its working to lower your blood sugar, meaning that initial feelings of lethargy could be due to your body adjusting to the new glucose levels

[11] Preventing Hiccups While Taking Ozempic Preventative strategies focus on minimising gastrointestinal disturbances and optimising medication tolerance, thereby reducing the likelihood of hiccup episodes during Ozempic therapy

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